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Risk factors and predictors of mortality of methicillin-resistant Staphylococcus aureus (MSRA) bacteraemia in HIV-infected patients

Author(s)M Tumbarello; K de Gaetano Donati; E Tacconelli; R Citton; T Spanu; F Leone; G Fadda and R Cauda
AbstractA 10-year prospective study (from 1991-2000) assessing the risk factors and outcomes for HIV-infected patients with MRSA compared to methicillin susceptible Staphylococcus aureus (MSSA) bacteraemia. Overall 31% (129/419) of bacteraemias were caused by Staphylococcus aureus (SA), of which 32% (41/129) were MRSA. Most MRSA bacteraemias were hospital acquired. Exposure to a-lactams, multiple hospital admissions (at least 4), and low CD4+ cell counts were risk factors associated with MRSA infection.The mortality rate was 34% in the MRSA group and 11% in the MSSA group, however high APACHE III score, and high HIV viraemia, but not methicillin resistance, were associated with increased risk of death (multivariate analysis).
Date of last revision by publisher05/24/2002
Date of last review by us03/20/2007
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Click here for full reviewChris CatchpoleAn assessment of the clinical impact, risk factors for, and mortality of HIV-infected patients with MRSA versus MSSA bacteraemia.. . .


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