| Doc Title | Dexamethasone for the treatment of tuberculous meningitis in adolescents and adults |
| Link | Click here for the original resource http://... |
| Author(s) | Guy E. Thwaites et al |
| Abstract | 545 patients over 14years old from two centres in Vietnam randomly allocated to dexamethasone or placebo in conjunction with standard quadruple antituberculous chemotherapy for TB meningitis.
No significant difference between groups in primary outcome (death or severe disability at 9 months)
Significantly reduced mortality in dexamethasone group (most marked in those with mild disease at entry)
Only significant secondary outcome was reduced time to fever clearance in steroid group
Mortality significantly higher amongst HIV-infected adults but no significant benefit from dexamethasone treatment
Significantly fewer adverse drug reactions to antituberculous therapy in dexamethasone group |
| Publisher | New England Journal of Medicine |
| Source | New England Journal of Medicine |
| Publication Type | Care guideline, Journal article |
| Category | Treatment |
| Level of Evidence | RCT |
| Coverage | National |
| Format | Html |
| Language | English |
| Access Rights | NeLH Core Content |
| Date of publishing | 10/21/2004 |
| Date of posting | 04/17/2005 |
| Date of last review by us | 04/17/2005 |