Tuberculosis National Knowledge Week provides an opportunity to present an update of quality assured information on subjects related to the diagnosis, management and control of TB. This page provides links to relevant evidence updates. The information is organised by topic areas and links are provided within each topic to the relevant references (systematic reviews, primary research) and guidelines where available.

• Introduction
• Evidence Updates - Citations
  • Treatment
  • Clinical Management & Diagnosis
  • Strain Typing
  • Public Health
  • Vaccination
  • TB & HIV
  • Tuberculous Meningitis
• Commentaries from Experts
  • Interferon Gamma Release Assay (IGRA) testing for TB – current status
  • X - DR TB; Emergence of a new global super bug
  • Tuberculosis in the European Region: Comparing East and West
• Resources from National Knowledge Service for TB
  • Substance misuse
  • Prisons
  • For staff working with asylum seekers
  • Children
  • Pregnancy
  • For Managers and Staff of Hostels for the homeless
• Useful Websites
  • Stop TB
  • World Health Organization - Tuberculosis
  • Health Protection Agency
  • NICE Guidelines
• Feedback Survey

• Rifabutin for treating pulmonary tuberculosis.
• Drugs for preventing tuberculosis in people at risk of multiple-drug-resistant pulmonary tuberculosis.
• Rifampicin plus pyrazinamide versus isoniazid for treating latent tuberculosis infection: a meta-analysis (Structured abstract)
• Biomarkers of treatment response in clinical trials of novel antituberculosis agents.
• Directly observed therapy for treating tuberculosis.
• Fluoroquinolones for treating tuberculosis.

• Clinical application of a rapid lung-orientated immunoassay in individuals with possible tuberculosis.
• How good are systemic symptoms and blood inflammatory markers at detecting individuals with tuberculosis?
• Predictive Value of a Whole-blood IFN-{gamma} Assay for the Development of Active TB Disease.
• Follow-up study of tuberculosis-exposed supermarket customers with negative tuberculin skin test results in association with positive gamma interferon release assay results.
• Incidence of Tuberculosis and the Predictive Value of ELISPOT and Mantoux Tests in Gambian Case Contacts.
• Sensitivity of IFN-gamma Release Assay to Detect Latent Tuberculosis Infection Is Retained in HIV-Infected Patients but Dependent on HIV/AIDS Progression.
• Prospective comparison of the tuberculin skin test and 2 whole-blood interferon-gamma release assays in persons with suspected tuberculosis.
• Meta-analysis: new tests for the diagnosis of latent tuberculosis infection: areas of uncertainty and recommendations for research.
• Patient choice promotes adherence in preventive treatment for latent tuberculosis.
• A systematic review of delay in the diagnosis and treatment of tuberculosis.

• Three-year population-based evaluation of standardized Mycobacterial Interspersed Repetitive Unit-Variable Number of Tandem Repeat typing of Mycobacterium tuberculosis.
• Nucleic acid amplification tests for the diagnosis of tuberculous lymphadenitis: a systematic review.
• Subcommittee on Antimicrobial Susceptibility Testing of Mycobacterium tuberculosis of the European Committee for Antimicrobial Susceptibility Testing (EUCAST) of the European Society of Clinical Microbiology and Infectious Diseases (ESCMID). Antimicrobial susceptibility testing of Mycobacterium tuberculosis (EUCAST document E.DEF 8.1)--report of the Subcommittee on Antimicrobial Susceptibility Testing of Mycobacterium tuberculosis of the European Committee for Antimicrobial Susceptibility Testing (EUCAST) of the European Society of Clinical Microbiology and Infectious Diseases (ESCMID)
• Large sequence polymorphisms classify Mycobacterium tuberculosis strains with ancestral spoligotyping patterns.
• Global phylogeography of Mycobacterium tuberculosis and implications for tuberculosis product development.
• Utility of genotyping of Mycobacterium tuberculosis in the contact investigation: a decision analysis.

• Survey of hospital incidents in hospital healthcare workers, England, and Wales 2005.
• Monitoring tuberculosis treatment outcome: analysis of national surveillance data from a clinical perspective.
• Measuring tuberculosis burden, trends, and the impact of control programmes.
• Tuberculosis in non-UK-born persons, England and Wales, 2001-2003.
• The evolution of extensively drug resistant tuberculosis (XDR-TB): history, status and issues for global control.

• A DNA vaccine against tuberculosis based on the 65 kDa heat-shock protein differentially activates human macrophages and dendritic cells.
• Progression of pulmonary tuberculosis and efficiency of bacillus Calmette-Guérin vaccination are genetically controlled via a common sst1-mediated mechanism of innate immunity.

• The growing impact of HIV infection on the epidemiology of tuberculosis in England and Wales: 1999 2003.
• Mycobacterial T Cell Responses in HIV-Infected Patients with Advanced Immunosuppression.
• Tuberculosis-associated immune reconstitution disease: incidence, risk factors and impact in an antiretroviral treatment service in South Africa.
• Immune Reconstitution and "Unmasking" of Tuberculosis during Antiretroviral Therapy.

• Multidrug-resistant tuberculous meningitis.
• Corticosteroids for managing tuberculous meningitis.

• Information resources on TB and substance misuse
  • Substance misuse and TB: Guidance for those affected
  • Substance misuse and TB: Guidance for families
  • Substance misuse and TB: for key workers (care workers, social workers, project workers and health professionals)
• Information resources on TB in prisons
  • Information about TB for people in prisons
  • Got TB? Read This! – information for those diagnosed with TB
  • Tuberculosis (TB): Guidance for Prison Officials
• Tuberculosis (TB): Guidance for staff working with people seeking asylum
• TB and children: guidance for all those who work with children
• Information resources for Pregnancy and Tuberculosis
  • Guidance for clinicians
  • Patient and public information sheet
• Information resources for Managers and Staff of Hostels for the homeless
  • Guidance for homeless service managers
  • Guidance for homes sector staff