Review - Reviewer's Assessment

1. Short summary / abstract
The Department of Health committee (SACAR) asked a joint working party of infection experts to revise previous guidelines on the prevention and control of MRSA infections and to extend the scope to include treatment and prophylaxis of MRSA infections and also laboratory diagnosis & susceptibility testing of MRSA. One of a set of three, these are the first UK guidelines focussing on the treatment and prophylaxis of MRSA infection. These evidence-based guidelines were produced after an extensive literature review and were further informed by antibiotic susceptibility data on MRSA from the UK. Recommendations are given for the treatment of common infections caused by MRSA, elimination of MRSA from carriage sites and prophylaxis of surgical site infection. There are several antibiotics currently available that are suitable for use in the management of this problem and potentially useful new agents are continuing to emerge.


2. What question is the document addressing?
These evidence based guidelines provide updated guidance for prophylaxis and treatment of MRSA in the UK.

3. Type of study
Guidelines

4. Methods valid & appropriate?
Yes

Comments:


5. Results / recommendations reliable?
Yes

6. Any major problems and biases?


7. Any other important / relevant studies which confirm or contradict?
1. Guidelines for the laboratory diagnosis and susceptibility testing of methicillin-resistant Staphylococcus aureus (MRSA)
http://jac.oxfordjournals.org/cgi/reprint/56/6/1000?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=1&andorexacttitle=and&titleabstract=diagnosis+susceptibility+MRSA&andorexacttitleabs=and&andorexactfulltext=and&searchid=1141392812221_592&FIRSTINDEX=0&sortspec=relevance&journalcode=jac
2. Guidelines for the Control and Prevention of Meticillin-Resistant Staphylococcus aureus (MRSA) in hospitals
http://www.bsac.org.uk/latest_news.cfm?cit_id=611&FAArea1=customWidgets.content_view_1&usecache=false
3. Revised Methicillin-Resistant Staphylococcus Aureus (MRSA) Infection Control for Hospitals http://www.his.org.uk/_db/_documents/MRSA_Guidelines_final_(revised)_aug98.doc


8. Keywords
Methicillin MRSA Guidelines Evidence-Based



Reviewer's Details:

Name:Jane Mani-Saada with assistance from Manjit Affley PhD BPharm(Hons) MRPharmS (Senior Scientific Adviser Pfizer Anti-infectives)
Post:Information Assistant
Affiliations
(Society / Organisation / Advisory Committee):


*** Note: These are the views of a professional expert rather than an official statement from his or her society, organisation or advisory committee.






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