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Dexamethasone for the treatment of tuberculous meningitis in adolescents and adults

Author(s)Guy E. Thwaites et al
Abstract545 patients over 14years old from two centres in Vietnam randomly allocated to dexamethasone or placebo in conjunction with standard quadruple antituberculous chemotherapy for TB meningitis.
No significant difference between groups in primary outcome (death or severe disability at 9 months)
Significantly reduced mortality in dexamethasone group (most marked in those with mild disease at entry)
Only significant secondary outcome was reduced time to fever clearance in steroid group
Mortality significantly higher amongst HIV-infected adults but no significant benefit from dexamethasone treatment
Significantly fewer adverse drug reactions to antituberculous therapy in dexamethasone group
Date of publishing10/21/2004
Date of last review by us04/17/2005
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Click here for full reviewRichard LessellsDoes adjunctive corticosteroid therapy in conjunction with antituberculous chemotherapy reduce the risk of disability or death in adults with tuberculous meningitis? . . .


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