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Consumption of imipenem correlates with b-lactam resistance in Pseudomonas aeruginosa

Author(s)Philipp M. Lepper; Eberhard Grusa; Helga Reichl; Josef H and Matthias Trautmann
AbstractThe consumption of anti-pseudomonal antibiotics and the resistance rates of P. aeruginosa were monitored over a 3-year period. Prescription of imipenem varied significantly over the study period. A high usage was followed by a reduction during a period of imipenem restriction. Prescription rates increased again when the restriction was relaxed. Rates of imipenem resistance in P. aeruginosa showed a time course similar to rate of consumption. Monthly rates of resistance to imipenem, ceftazidime and piperacillin-tazobactam were significantly associated with imipenem prescription rates in the same and preceding month. Consumption of ceftazidime and piperacillin-tazobactam had no association with resistance.
Date of last revision by publisher01/01/2002
Date of last review by us08/01/2007
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Click here for full reviewTim WellerDoes the resistance rate in P. aeruginosa correlate with the rate of consumption of anti-pseudomonal antibiotics? . . .


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