|Abstract||Diagnosis, treatment, and follow-up of HPV-related lesions in HIV-infected patients should be performed in consultation with a clinician experienced in the management of HPV and HIV.|
Human papillomaviruses (HPV) are a large group of viruses that are prevalent in the sexually active population and are capable of infecting squamous epithelia. A subgroup of approximately 30 different HPV types have a predilection for the anogenital tract and may cause asymptomatic infection, condylomata acuminata (genital warts), squamous intraepithelial neoplasia, and rarely cervical neoplasia or other anogenital carcinomas. In the United States, HPV types 16 and 18 are responsible for the development of approximately 70% of cervical and anal dysplasia and cancer. HPV types 6 and 11 account for approximately 90% of benign genital warts. Patients infected with HPV may be infected with more than one HPV type and can be at risk for both dysplasia and benign disease.
The prevalence of HPV in HIV-infected patients is higher than in non-HIV-infected individuals and varies over time and with the degree of immunosuppression. With increased immunosuppression, anogenital warts may become extensive, may frequently relapse after treatment, and are more likely to be dysplastic.