Resource Details


Genital herpes simplex virus (HSV)

Author(s)New York State Department of Health - State/Local Government Agency [U.S.]
AbstractThis US guideline includes information about the following topics:

- Diagnosis
- Treatment
- Acyclovir-Resistant HSV
- Prevention of Transmission
- Prevention of HIV Transmission
- Management of Sex Partners
- Management of HIV Exposure
- Management of HSV Exposure

Herpes simplex virus (HSV) is the etiologic agent of genital herpes. Infection with either of the two identified serotypes, HSV-1 or HSV-2, is lifelong. Most genital herpes is caused by HSV-2, whereas most orolabial herpes is caused by HSV-1. However, each serotype can cause disease in either location, and genital HSV-1 may often be acquired through contact with a partner’s mouth. Perinatal transmission can also occur, particularly when the mother experiences a primary infection during pregnancy. (For treatment of genital herpes in pregnant HIV-infected women, see Management of HIV-Infected Pregnant Women Including Prevention of Perinatal HIV Transmission.)

Serologic studies have documented HSV seropositivity in the overwhelming majority of HIV-infected patients (>95% in some series). Orolabial and anogenital disease caused by HSV in HIV-infected patients may vary from that in the non-HIV-infected populations in severity of initial infection or severity or frequency of recurrence. Another difference is that acyclovir resistance is rarely encountered in a non-HIV-infected host, but its frequency is increased in the HIV-infected population. Nevertheless, recommendations for treatment and prophylaxis are similar for the two patient groups.
Date of publishing10/09/2007
Date of last review by us12/06/2007
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