Resource Details

Title

Effectiveness of early switch from intravenous to oral antibiotics in severe community acquired pneumonia: multicentre randomised trial

Author(s)Jan Jelrik Oosterheert et al.
AbstractThis study aimed to compare the effectiveness of an early switch to oral antibiotics with the standard 7 day course of intravenous antibiotics in severe community acquired pneumonia in a multicentre randomised controlled trial which took place in 5 teaching hospitals and 2 university medical centres in the Netherlands.

302 patients in non-intensive care wards with severe community acquired pneumonia participated, 265 patients fulfilled the study requirements. The study was carried out using 3 days of treatment with intravenous antibiotics followed, when clinically stable, by oral antibiotics or by 7 days of intravenous antibiotics. The main outcome measures were clinical cure and length of hospital stay.

The authors concluded that the early switch from intravenous to oral antibiotics in patients with severe community acquired pneumonia was safe and decreased length of hospital stay by 2 days.
Date of publishing11/07/2006
Date of last review by us12/20/2006
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