| Title | Mycobacterial T Cell Responses in HIV-Infected Patients with Advanced Immunosuppression |
| Link | http://www.journals.uchicago.edu/doi/abs/10.1086/524685 |
| Attached Resource |  |
| Full text (for search) | |
| Author(s) | Hammond AS; McConkey SJ; Hill PC; Crozier S; Klein MR; Adegbola RA; Rowland-Jones S; Brookes RH; Whittle H; Jaye A. |
| Abstract | Antimycobacterial T cell reactivity at different stages of HIV infection was investigated. Subjects were screened with purified protein derivative (PPD), early secreted antigenic target (ESAT)-6, and culture filtrate protein (CFP)-10 antigens for interferon (IFN)-gamma-producing effector T cell responses by direct ex vivo enzyme-linked immunospot (ELISpot) assay. The proportion of responders to PPD tuberculin decreased with a reduction in CD4 T cell count, whereas the proportion of responder to ESAT-6 and CFP-10 did not. The main sources of IFN-gamma secretion were CD4 cells, and the relative responses to ESAT-6 and CFP-10 significantly increased in HIV-infected patients with decreasing CD4 cell count. This may reflect early signs of reactivation, reinfection, or a restricted, inefficient immune response to Mycobacterium tuberculosis. |
| Peer Reviewer | |
| Publisher | University of Chicago Press |
| Source | Journal of Infectious Diseases |
| Publication Type | Research study |
| Category | Investigation |
| Level of Evidence | Clinical trial, Evidence cited |
| Coverage | International |
| Gambia, The |
| Format | Pdf |
| Language | English |
| Access Rights | Site-specific password |
| Date of publishing | 01/15/2008 |
| Date of last review by us | 03/06/2008 |